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Glycerophospholipid metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
sterol + phosphatidylcholine <=> lysophosphatidylcholine + sterol_ester 2.3.1.43 phosphatidylcholine---sterol O-acyltransferase
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S-adenosyl-L-methionine + Phosphoethanolamine <=> H+ + S-adenosyl-L-homocysteine + N-methylethanolamine_phosphate 2.1.1.103 phosphoethanolamine N-methyltransferase
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S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine <=> phosphatidylcholine + S-adenosyl-L-homocysteine + H+ 2.1.1.16 methylene-fatty-acyl-phospholipid synthase
2.1.1.17 phosphatidylethanolamine N-methyltransferase
2.1.1.71 phosphatidyl-N-methylethanolamine N-methyltransferase
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acyl-CoA + Monolysocardiolipin <=> CoA + cardiolipin 2.3.1
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CDP-glycerol + H2O <=> H+ + sn-glycerol_3-phosphate + CMP 3.6.1.13 ADP-ribose diphosphatase
3.6.1.16 CDP-glycerol diphosphatase
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glycerophosphocholine + H2O <=> sn-glycerol_3-phosphate + choline + H+ 3.1.4.2 glycerophosphocholine phosphodiesterase
3.1.4.44 glycerophosphoinositol glycerophosphodiesterase
3.1.4.46 glycerophosphodiester phosphodiesterase
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L-serine-phosphoethanolamine + H2O <=> Phosphoethanolamine + L-serine + H+ 3.1.4.13 serine-ethanolaminephosphate phosphodiesterase
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H+ + Phosphoethanolamine + CTP <=> CDP-ethanolamine + diphosphate 2.7.7.14 ethanolamine-phosphate cytidylyltransferase
2.7.7.15 choline-phosphate cytidylyltransferase
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acyl-CoA + 1-acylglycerophosphoinositol <=> CoA + phosphatidylinositol 2.3.1
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glycerophosphoethanolamine + H2O <=> sn-glycerol_3-phosphate + ethanolamine + H+ 3.1.4.2 glycerophosphocholine phosphodiesterase
3.1.4.46 glycerophosphodiester phosphodiesterase
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phosphatidic_acid + H2O <=> diacylglycerol + phosphate 3.1.3.4 phosphatidate phosphatase
3.1.3.81 diacylglycerol diphosphate phosphatase
3.1.4.3 phospholipase C
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CDP-diacylglycerol + H2O <=> phosphatidic_acid + CMP + H+ 2.7.8.8 CDP-diacylglycerol---serine O-phosphatidyltransferase
3.6.1.26 CDP-diacylglycerol diphosphatase
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ethanolamine <=> NH3 + acetaldehyde 4.3.1.7 ethanolamine ammonia-lyase
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acyl-CoA + 1-acyl-glycerophosphoglycerol <=> CoA + phosphatidylglycerol 2.3.1
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acyl-CoA + sn-glycerol_3-phosphate <=> lysophosphatidic_acid + CoA 2.3.1.15 glycerol-3-phosphate 1-O-acyltransferase
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H+ + sn-glycerol_3-phosphate + CTP <=> CDP-glycerol + diphosphate 2.7.7.39 glycerol-3-phosphate cytidylyltransferase
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acyl_phosphate + sn-glycerol_3-phosphate <=> lysophosphatidic_acid + phosphate 2.3.1.275 acyl phosphate:glycerol-3-phosphate acyltransferase
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phosphatidylserine + H2O <=> 2-acyl-sn-glycero-3-phosphoserine + fatty_acid + H+ 3.1.1.111 phosphatidylserine sn-1 acylhydrolase
3.1.1.32 phospholipase A1
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CTP + phosphocholine + H+ <=> CDP-choline + diphosphate 2.7.7.15 choline-phosphate cytidylyltransferase
2.7.7.57 N-methylphosphoethanolamine cytidylyltransferase
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ATP + diacylglycerol <=> H+ + phosphatidic_acid + ADP 2.7.1.107 diacylglycerol kinase (ATP)
2.7.1.138 ceramide kinase
2.7.1.94 acylglycerol kinase
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H2O + Acetylcholine <=> H+ + acetate + choline 3.1.1.7 acetylcholinesterase
3.1.1.8 cholinesterase
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lysophosphatidylcholine + H2O <=> glycerophosphocholine + fatty_acid 3.1.1.23 acylglycerol lipase
3.1.1.32 phospholipase A1
3.1.1.5 lysophospholipase
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phosphatidylethanolamine + CoA <=> 1-acyl-sn-glycero-3-phosphoethanolamine + acyl-CoA 2.3.1.23 1-acylglycerophosphocholine O-acyltransferase
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CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine <=> 2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phospho-L-serine + CMP + H+ 2.7.8.38 archaetidylserine synthase
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CDP-diacylglycerol + myo-inositol <=> phosphatidylinositol + CMP + H+ 2.7.8.11 CDP-diacylglycerol---inositol 3-phosphatidyltransferase
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S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine <=> phosphatidyl-N,N-dimethylethanolamine + H+ + S-adenosyl-L-homocysteine 2.1.1.103 phosphoethanolamine N-methyltransferase
2.1.1.16 methylene-fatty-acyl-phospholipid synthase
2.1.1.17 phosphatidylethanolamine N-methyltransferase
2.1.1.71 phosphatidyl-N-methylethanolamine N-methyltransferase
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acyl-CoA + 1-acyl-sn-glycero-3-phosphoserine <=> CoA + phosphatidylserine 2.3.1
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CTP + phosphatidic_acid + H+ <=> CDP-diacylglycerol + diphosphate 2.7.7.41 phosphatidate cytidylyltransferase
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L-alpha-glycerophosphate + NADP+ <=> dihydroxyacetone_phosphate + NADPH + H+ 1.1.1.156 glycerol 2-dehydrogenase (NADP+)
1.1.1.191 indole-3-acetaldehyde reductase (NADPH)
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.21 aldose reductase
1.1.1.261 sn-glycerol-1-phosphate dehydrogenase
1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+)
1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+)
1.1.1.94 glycerol-3-phosphate dehydrogenase [NAD(P)+]
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
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phosphatidylethanolamine + H2O <=> fatty_acid + 1-acyl-sn-glycero-3-phosphoethanolamine + H+ 3.1.1.4 phospholipase A2
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S-adenosyl-L-methionine + diacylglycerol <=> Diacylglycerylhomoserine + S-methyl-5''-thioadenosine + H+ not assigned
 –
2,3-bis-O-phytanyl-sn-glycerol_1-phosphate + NADP+ <=> 2,3-bis-(O-geranylgeranyl)-sn-glycerol_1-phosphate + NADPH + H+ 1.3.1.101 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H]
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ethanolamine + acetaldehyde <=> diethanolamine 4.3.3
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CDP-diacylglycerol + sn-glycerol_3-phosphate <=> CMP + 1-(3-sn-phosphatidyl)-sn-glycerol_3-phosphate + H+ 2.7.8.5 CDP-diacylglycerol---glycerol-3-phosphate 1-phosphatidyltransferase
2.7.8.8 CDP-diacylglycerol---serine O-phosphatidyltransferase
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2,3-bis-(O-geranylgeranyl)-sn-glycerol_1-phosphate + reduced_acceptor <=> 2,3-bis-O-phytanyl-sn-glycerol_1-phosphate + acceptor 1.3.7.11 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase
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phosphatidylglycerophosphate + H2O <=> phosphatidylglycerol + phosphate 3.1.3.27 phosphatidylglycerophosphatase
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O2 + sn-glycerol_3-phosphate <=> H2O2 + dihydroxyacetone_phosphate 1.1.3.21 glycerol-3-phosphate oxidase
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phosphocholine + H2O <=> choline + phosphate 3.1.3.1 alkaline phosphatase
3.1.3.2 acid phosphatase
3.1.3.75 phosphoethanolamine/phosphocholine phosphatase
3.1.6.6 choline-sulfatase
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phosphatidylserine + H+ <=> phosphatidylethanolamine + CO2 4.1.1.65 phosphatidylserine decarboxylase
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2,3-bis-O-phytanyl-sn-glycerol_1-phosphate + NAD+ <=> 2,3-bis-(O-geranylgeranyl)-sn-glycerol_1-phosphate + NADH + H+ 1.3.1.101 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H]
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L-alpha-glycerophosphate + geranylgeranyl_diphosphate <=> 3-(O-geranylgeranyl)-sn-glycerol_1-phosphate + diphosphate 2.5.1.41 phosphoglycerol geranylgeranyltransferase
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acyl-[acyl-carrier_protein] + 2-acylglycerophosphoethanolamine <=> [acyl-carrier_protein] + phosphatidylethanolamine 2.3.1.40 acyl-[acyl-carrier-protein]---phospholipid O-acyltransferase
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3-(O-geranylgeranyl)-sn-glycerol_1-phosphate + geranylgeranyl_diphosphate <=> 2,3-bis-(O-geranylgeranyl)-sn-glycerol_1-phosphate + diphosphate 2.5.1.42 geranylgeranylglycerol-phosphate geranylgeranyltransferase
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phosphatidylethanolamine + L-serine <=> phosphatidylserine + ethanolamine 2.7.8.29 L-serine-phosphatidylethanolamine phosphatidyltransferase
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CTP + diacylglycerol <=> CDP + phosphatidic_acid + H+ 2.7.1.174 diacylglycerol kinase (CTP)
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choline + CDP-diacylglycerol <=> phosphatidylcholine + CMP + H+ 2.7.8.24 phosphatidylcholine synthase
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2-acylglycerophosphoethanolamine + H2O <=> fatty_acid + glycerophosphoethanolamine 3.1.1.5 lysophospholipase
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S-adenosyl-L-methionine + N-methylethanolamine_phosphate <=> H+ + phosphodimethylethanolamine + S-adenosyl-L-homocysteine 2.1.1.103 phosphoethanolamine N-methyltransferase
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acyl-CoA + sn-glycerol_3-phosphate <=> CoA + 2-acyl-sn-glycerol_3-phosphate 2.3.1.15 glycerol-3-phosphate 1-O-acyltransferase
2.3.1.198 glycerol-3-phosphate 2-O-acyltransferase
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2,3-bis-(O-geranylgeranyl)-sn-glycerol_1-phosphate + CTP + H+ <=> CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate 2.7.7.67 CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase
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S-adenosyl-L-methionine + Diacylglycerylhomoserine <=> Diacylglyceryl-N,N,N-trimethylhomoserine + S-adenosyl-L-homocysteine + H+ 2.1.1.M42
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1-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> fatty_acid + glycerophosphoethanolamine 3.1.1.5 lysophospholipase
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CDP-diacylglycerol + phosphatidylglycerol <=> cardiolipin + CMP 2.7.8.41 cardiolipin synthase (CMP-forming)
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triethanolamine <=> diethanolamine + acetaldehyde 4.3.3
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choline + acetyl-CoA <=> Acetylcholine + CoA 2.3.1.6 choline O-acetyltransferase
2.3.1.7 carnitine O-acetyltransferase
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CDP-diacylglycerol + L-serine <=> CMP + phosphatidylserine + H+ 2.7.8.38 archaetidylserine synthase
2.7.8.8 CDP-diacylglycerol---serine O-phosphatidyltransferase
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phosphatidylethanolamine + H2O <=> diacylglycerol + Phosphoethanolamine 3.1.4.12 sphingomyelin phosphodiesterase
3.1.4.3 phospholipase C
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S-adenosyl-L-methionine + phosphatidylethanolamine <=> phosphatidyl-N-methylethanolamine + S-adenosyl-L-homocysteine + H+ 2.1.1.17 phosphatidylethanolamine N-methyltransferase
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ethanolamine + ATP <=> H+ + Phosphoethanolamine + ADP 2.7.1.32 choline kinase
2.7.1.82 ethanolamine kinase
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phosphatidylcholine + L-serine <=> phosphatidylserine + choline 2.7.8.29 L-serine-phosphatidylethanolamine phosphatidyltransferase
3.1.4.4 phospholipase D
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L-alpha-glycerophosphate + NADP+ <=> dihydroxyacetone_phosphate + NADPH + H+ 1.1.1.156 glycerol 2-dehydrogenase (NADP+)
1.1.1.191 indole-3-acetaldehyde reductase (NADPH)
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.21 aldose reductase
1.1.1.261 sn-glycerol-1-phosphate dehydrogenase
1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+)
1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+)
1.1.1.94 glycerol-3-phosphate dehydrogenase [NAD(P)+]
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
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L-alpha-glycerophosphate + NAD+ <=> dihydroxyacetone_phosphate + NADH + H+ 1.1.1.1 alcohol dehydrogenase
1.1.1.261 sn-glycerol-1-phosphate dehydrogenase
1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+)
1.1.1.94 glycerol-3-phosphate dehydrogenase [NAD(P)+]
1.1.5.3 glycerol-3-phosphate dehydrogenase
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acyl-CoA + lysophosphatidic_acid <=> phosphatidic_acid + CoA 2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferase
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choline + ATP <=> H+ + phosphocholine + ADP 2.7.1.32 choline kinase
2.7.1.82 ethanolamine kinase
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phosphatidylethanolamine + H2O <=> 2-acylglycerophosphoethanolamine + fatty_acid + H+ 3.1.1.32 phospholipase A1
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diacylglycerol + CDP-ethanolamine <=> phosphatidylethanolamine + CMP + H+ 2.7.8.1 ethanolaminephosphotransferase
2.7.8.2 diacylglycerol cholinephosphotransferase
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acyl-CoA + dihydroxyacetone_phosphate <=> CoA + acyldihydroxyacetone_phosphate 2.3.1.42 glycerone-phosphate O-acyltransferase
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phosphatidylcholine + H2O <=> phosphatidic_acid + choline + H+ 3.1.4.4 phospholipase D
3.1.4.41 sphingomyelin phosphodiesterase D
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phosphatidylglycerol + phosphatidylglycerol <=> cardiolipin + glycerol 2.7.8
2.7.8.B10
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diacylglycerol + CDP-choline <=> phosphatidylcholine + CMP + H+ 2.7.8.1 ethanolaminephosphotransferase
2.7.8.2 diacylglycerol cholinephosphotransferase
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S-adenosyl-L-methionine + phosphodimethylethanolamine <=> H+ + phosphocholine + S-adenosyl-L-homocysteine 2.1.1.103 phosphoethanolamine N-methyltransferase
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phosphatidylinositol + H2O <=> 1-acylglycerophosphoinositol + a_carboxylate 3.1.1.52 phosphatidylinositol deacylase
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2-acylglycerophosphocholine + acyl-CoA <=> phosphatidylcholine + CoA 2.3.1.62 2-acylglycerophosphocholine O-acyltransferase
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phosphatidylglycerol + H2O <=> diacylglycerol + sn-glycerol_3-phosphate 3.1.4
3.1.4.12 sphingomyelin phosphodiesterase
3.1.4.3 phospholipase C
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L-serine + CDP-ethanolamine <=> H+ + L-serine-phosphoethanolamine + CMP 2.7.8.4 serine-phosphoethanolamine synthase
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L-alpha-glycerophosphate + NAD+ <=> dihydroxyacetone_phosphate + NADH + H+ 1.1.1.1 alcohol dehydrogenase
1.1.1.261 sn-glycerol-1-phosphate dehydrogenase
1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+)
1.1.1.94 glycerol-3-phosphate dehydrogenase [NAD(P)+]
1.1.5.3 glycerol-3-phosphate dehydrogenase
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phosphatidylcholine + H2O <=> 2-acylglycerophosphocholine + fatty_acid + H+ 3.1.1.32 phospholipase A1
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acyldihydroxyacetone_phosphate + NADPH <=> lysophosphatidic_acid + NADP+ 1.1.1.101 acylglycerone-phosphate reductase
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sn-glycerol_3-phosphate + FAD <=> dihydroxyacetone_phosphate + FADH2 1.1.5.3 glycerol-3-phosphate dehydrogenase
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Phosphoethanolamine + H2O <=> ethanolamine + phosphate 3.1.3.1 alkaline phosphatase
3.1.3.2 acid phosphatase
3.1.3.75 phosphoethanolamine/phosphocholine phosphatase
3.6.1.1 inorganic diphosphatase
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phosphatidylglycerol + phosphatidylethanolamine <=> cardiolipin + ethanolamine 2.7.8
2.7.8.B11
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phosphatidylcholine + H2O <=> lysophosphatidylcholine + fatty_acid + H+ 3.1.1.26 galactolipase
3.1.1.32 phospholipase A1
3.1.1.4 phospholipase A2
3.1.1.5 lysophospholipase
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phosphatidylethanolamine + H2O <=> ethanolamine + phosphatidic_acid 3.1.4.4 phospholipase D
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acyl-CoA + lysophosphatidylcholine <=> phosphatidylcholine + CoA 2.3.1.23 1-acylglycerophosphocholine O-acyltransferase
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acyl-CoA + 2-acyl-sn-glycerol_3-phosphate <=> phosphatidic_acid + CoA 2.3.1.52 2-acylglycerol-3-phosphate O-acyltransferase
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phosphatidylcholine + H2O <=> diacylglycerol + phosphocholine + H+ 3.1.1.4 phospholipase A2
3.1.4.12 sphingomyelin phosphodiesterase
3.1.4.3 phospholipase C
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2-acylglycerophosphocholine + H2O <=> fatty_acid + glycerophosphocholine 3.1.1.32 phospholipase A1
3.1.1.5 lysophospholipase
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cardiolipin + H2O <=> Monolysocardiolipin + fatty_acid 3.1.1
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H2O + Phosphoethanolamine <=> NH3 + phosphate + acetaldehyde 4.2.3.2 ethanolamine-phosphate phospho-lyase
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Visualization of the pathway